For each of the following metallo-proteins identify the metal-ion at the active-site and the function of the… · ABC26IN0551
Subject: Inorganic Chemistry · Chapter: Bioinorganic Chemistry · Topic: Bioinorganic – General · Exam: JAM 2005-2022 · Marks: 2 · Difficulty: Medium
For each of the following metallo-proteins identify the metal-ion at the active-site and the function of the proteins: deoxy-hemoglobin, deoxy-myoglobin, oxy-hemocyanin, cytochrome-C and carbonic anhydrase.
Answer
SELF-PRACTICE — the source book printed no answer.
Nothing is invented here, so this question has no answer on record.
Explanation
Answer: Deoxy-Hb: Fe²⁺, O₂ transport; deoxy-Mb: Fe²⁺, O₂ storage; oxy-hemocyanin: Cu(II), non-heme O₂ transport; cytochrome c: Fe (Fe²⁺/Fe³⁺), electron transfer; carbonic anhydrase: Zn²⁺, CO₂ ⇌ HCO₃⁻ hydration — All three iron proteins are heme proteins. Hemocyanin binds O₂ between two Cu centres (Cu(I) in the deoxy form, Cu(II)–peroxide in the oxy form). Carbonic anhydrase uses Zn–OH⁻ as the nucleophile.