Q16 · CSIR-NET Chemistry, December 2012
Paper: CSIR-NET December 2012 · Subject: Organic Chemistry · Chapter: Natural Products · Topic: Natural Products – General · Marks: 2 · Difficulty: Medium
Match the following biochemical transformations with coenzymes involved | (i) $\alpha$-ketoglutarate to glutamic acid | (A) tetrahydrofolate |
|---|
| (ii) uridine to thymidine | (B) NADH |
| (iii) pyruvic acid to acetyl coenzyme A | (C) thiamine pyrophosphate |
| (D) pyridozamine |
(a)(i)-(D), (ii)-(A), (iii)-(C)
(b)(i)-(A), (ii)-(B), (iii)-(D)
(c)(i)-(B), (ii)-(A), (iii)-(C)
(d)(i)-(D), (ii)-(B), (iii)-(C)
Answer
Answer: A ✓ checked by 4AB · confidence medium
Explanation
α-Ketoglutarate → glutamate by transamination uses pyridoxal/pyridoxamine phosphate. dUMP → dTMP (thymidine) uses N⁵,N¹⁰-methylene-tetrahydrofolate. Pyruvate → acetyl-CoA (pyruvate dehydrogenase) uses thiamine pyrophosphate. i–D, ii–A, iii–C (a).
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