Q62 · CSIR-NET Chemistry, December 2019

Paper: CSIR-NET December 2019 · Subject: Inorganic Chemistry · Chapter: Bioinorganic Chemistry · Topic: Metal Toxicity Medicine · Marks: 2 · Difficulty: Medium

Choose the correct statements for oxymyoglobin and cytochrome $\mathrm{P_{450}}$ (resting state) from the following: A. Both contain dianion of protoporphyrin-IX B. They have same fifth-ligand bonded to metal centre from the protein backbone C. They contain single active site D. They contain metal ion in +3 oxidation state
(a)A, B and C
(b)A, C and D
(c)A, B and D
(d)B and C only
Answer
Answer: B ✓ checked by 4AB · confidence medium
Explanation
Both contain protoporphyrin-IX²⁻ and a single heme site. Iron is formally Fe(III) in both: Fe(III)–O₂⁻ in oxymyoglobin and resting Fe(III) in P450. The fifth ligands differ: His in myoglobin, Cys thiolate in P450. A, C and D (b).

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