In human body cis- platin hydrolyzes to diaqua complex and modifies the DNA structure by binding to · ABC26IN0043
Subject: Inorganic Chemistry · Chapter: Bioinorganic Chemistry · Topic: Bioinorganic Chemistry – General · Exam: CSIR-NET 2016 · Marks: 2 · Difficulty: Medium
In human body cis- platin hydrolyzes to diaqua complex and modifies the DNA structure by binding to
(a)N-atom of guanine base
(c)N-atom of adenine base
(b)O-atom of cytosine base
(d)O-atom of thymine base
Answer
Answer: A ✓ checked by 4AB · confidence high
Explanation
Cisplatin's aqua species binds the N7 atom of guanine (1,2-intrastrand GpG cross-link) (a).
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