Choose the correct set of statements for cis-platin.
(A) It can be prepared from $\mathrm{K_2[PtCl_4]}$.
(B) It can be prepared from $\mathrm{[Pt(NH_3)_4Cl_2}$.
(C) In its preparation, the observed trans effect for $\mathrm{Cl^-}$ is greater than that of $\mathrm{NH_3}$
(D) In blood it stays in equilibrium with cis-$\mathrm{[Pt(NH_3)_2Cl(H_2O)]^{+}}$
(E) In DNA strand, it binds to two adjacent cytosine bases.
The correct set is
(a)A, C and D
(b)A, C, D and E
(c)B, C and D
(d)B, C, D and E
Answer
Answer: A ✓ checked by 4AB · confidence medium
Answer: A, C and D.
Explanation
Answer: A, C and D — cis-Platin is made from K₂[PtCl₄] + NH₃. The first NH₃ enters and the larger trans effect of Cl⁻ directs the second NH₃ cis. In blood (≈100 mM Cl⁻) it remains mostly as the dichloro complex in equilibrium with a little aqua form. [Pt(NH₃)₄]Cl₂ + HCl gives the trans isomer. In DNA it binds two adjacent guanines (N7), not cytosines.