In the following reaction, the stereochemistry of the major product is predicted by the · ABC26IN0531
Subject: Inorganic Chemistry · Chapter: Organometallic Compounds · Topic: Organometallic Compounds – General · Exam: GATE 2005-2021 · Marks: 2 · Difficulty: Medium
In the following reaction, the stereochemistry of the major product is predicted by the 
(a)Cram's model
(b)Cram's chelation model
(c)Felkin model
(d)Felkin-Anh model
Answer
Answer: B ✓ checked by 4AB · confidence high
The source book printed no answer; this one was worked out and checked — see the explanation.
Explanation
The α-methoxy group chelates the lithium together with the carbonyl oxygen, locking the conformation; EtLi attacks from the less hindered side — Cram's chelation (cyclic) model.
Study loop for Organometallic Compounds