In the catalytic hydration of $\mathrm{CO}_{2}$ by carbonic anhydrase, $\mathrm{CO}_{2}$ first interacts with
(a)OH group of the active site of the enzyme and then with zinc
(b)$\mathrm{H}_{2} \mathrm{O}$ of the active site of the enzyme and then with zinc
(c)zinc of the active site of the enzyme and then with OH group
(d)zinc of the active site of the enzyme and then with $\mathrm{H}_{2} \mathrm{O}$
Answer
Answer: A ✓ checked by 4AB · confidence high
Explanation
The zinc-bound hydroxide attacks CO₂ (nucleophilic attack on carbon); the resulting bicarbonate then coordinates to zinc before being displaced by water.