Treatment of the pentapeptide Gly-Arg-Phe-Ala-Ala, in separate experiments, with the enzymes Trypsin… · ABC26OR0501

Subject: Organic Chemistry · Chapter: Natural Products · Topic: Natural Products & – General · Exam: GATE 2000-2022 · Marks: 2 · Difficulty: Medium

Treatment of the pentapeptide Gly-Arg-Phe-Ala-Ala, in separate experiments, with the enzymes Trypsin, Chemotrypsin and Carboxypeptidase A respectively, gives :
(a)Gly-Arg + Phe-Ala-Ala; Gly-Arg-Phe+Ala-Ala; Gly-Arg-Phe-Ala+Ala
(b)Gly-Arg-Phe+Ala-Ala; Gly-Arg-Phe+Ala-Ala; Gly-Arg-Phe-Ala+Ala
(c)Gly-Arg+Phe-Ala-Ala; Gly-Arg-Phe-Ala+Ala; Gly-Arg-Phe+Ala-Ala
(d)Gly-Arg + Phe-Ala-Ala; Gly-Arg-Phe+Ala-Ala; Gly+ Arg-Phe-Ala + Ala
Answer
Answer: A ✓ checked by 4AB · confidence high
Explanation
Trypsin cuts after Arg (Gly-Arg + Phe-Ala-Ala), chymotrypsin after Phe (Gly-Arg-Phe + Ala-Ala), carboxypeptidase A releases the C-terminal Ala (a).

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