Q13 · CSIR NET Chemistry, June 2013
Paper: CSIR NET June 2013 · Subject: Organic Chemistry · Chapter: Natural Products · Topic: Natural Products – General · Marks: 2 · Difficulty: Medium
The major product formed in the reaction of guanosine with one equivalent of methyl iodide is
(a)
$\mathrm{I}^{\ominus}$
$\mathrm{I}^{\ominus}$(b)
(c)
$\mathrm{I}^{\ominus}$
$\mathrm{I}^{\ominus}$(d)
Answer
Answer: A ✓ checked by 4AB · confidence high
Explanation
Guanosine is alkylated first at N-7, the most nucleophilic nitrogen of the purine, giving the N-7-methylguanosinium iodide (a).
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