Let the missing number be $x$. Given $48.2 \times 2.5 \times 2.2+x=270$ $$\begin{aligned} & \Rightarrow x=270-48.2 \times 2.5 \times 2.2 \\ & x=270-265.1=4.9 \end{aligned}$$ Hence, the number is 4.9.
Explanation as extracted from the printed page; notation may be imperfect.